Cannabis is one of the earliest cultivated crops, grown in Taiwan for fiber starting about 10,000 years ago. The Emperor Shen-Nung, a pharmacologist, wrote a book on treatment methods in 2737 BCE that included the medical benefits of cannabis and recommended it for many ailments, including constipation, gout, rheumatism, and absent-mindedness.   
Published studies, with CBD, date back to the 1980s with one of the first completed on mice. These studies have continued throughout history to understand the importance of cannabinoids and the endocannabinoid system (ECS) as this system is present in all mammals, birds, reptiles, and fish. The following are the most recent published studies highlighting the amazing effect CBD has on all these wonderful creatures. 
 
Cannabidiol in canine epilepsy
https://www.sciencedirect.com/science/article/pii/S1090023322001289?via%3Dihub

Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
https://www.frontiersin.org/articles/10.3389/fvets.2022.977457/full

Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood
https://www.mdpi.com/2306-7381/8/9/185/htm

CBD study on dog comparing Nasal, Oral, and Rectal administration
https://www.frontiersin.org/articles/10.3389/fvets.2022.899940/full

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain.  Study (2020) by Baylor
https://journals.lww.com/pain/Fulltext/2020/09000/A_randomized,_double_blind,_placebo_controlled.24.aspx

US Veterinarians' Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions
https://www.frontiersin.org/articles/10.3389/fvets.2018.00338/full

Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy
https://www.ncbi.nlm.nih.gov/pubmed/31067185

Cannabis sativa L. may reduce aggressive behavior towards humans in shelter dogs
https://www.nature.com/articles/s41598-021-82439-2

Cannabinoid receptors in invertebrates
https://onlinelibrary.wiley.com/doi/10.1111/j.1420-9101.2005.01028.x

Drug-drug interaction between cannabidiol and phenobarbital in healthy dogs
https://pubmed.ncbi.nlm.nih.gov/34727050/


The above information is purely for educational purposes and not to treat, diagnose, or cure any ailment.  Please check with your Veterinarian prior to use.