Peer-Reviewed Research

The Science Behind
King Kanine

We don't just claim our CBD works — we back it with published, peer-reviewed science. Every formula is built on a foundation of real research.

8 Published Studies
100% Peer-Reviewed
Est. 1980s CBD Research History
Vet-Recognized By Licensed Veterinarians

Why It Matters

A History Rooted in Science

Cannabis has been cultivated for over 10,000 years, and published CBD studies date back to the 1980s. The endocannabinoid system — the biological network CBD interacts with — is not unique to humans. It exists across mammals, birds, reptiles, and fish.

At King Kanine, we believe pet owners deserve access to the same rigorous science that guides veterinary professionals. Every study below has been published in a peer-reviewed journal and is freely accessible for your review.

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Endocannabinoid System

All mammals share the ECS — the same system CBD interacts with in humans.

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Double-Blind Trials

Multiple studies use the gold standard randomized, placebo-controlled methodology.

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University-Backed

Research published by Baylor University, Frontiers, and leading veterinary journals.

Published Research

All 8 Studies

01 Anxiety

Ashwagandha and Stress/Anxiety in Dogs

Ashwagandha supplementation was associated with reduced stress markers and calmer behavior in dogs during stressful situations.

ScienceDirect — Veterinary Behavioural Science

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02 Epilepsy

Cannabidiol in Canine Epilepsy

CBD treatment significantly reduced seizure frequency in dogs with idiopathic epilepsy compared to placebo.

ScienceDirect — Journal of Veterinary Internal Medicine

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03 Safety & Tolerance

Long-Term Daily Feeding of CBD is Well-Tolerated by Healthy Dogs

Daily CBD supplementation over 6 months showed no adverse health effects and was well-tolerated across all dose groups.

Frontiers in Veterinary Science

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04 Inflammation

Effect of CBD on Canine Inflammatory Response

CBD demonstrated a meaningful reduction in inflammatory markers in canine whole blood — supporting its use for inflammatory conditions.

MDPI — Veterinary Sciences

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05 Pharmacokinetics

CBD in Dogs: Comparing Nasal, Oral, and Rectal Administration

Oral administration achieved the most consistent and sustained plasma CBD levels — validating oil and treat formats for daily use.

Frontiers in Veterinary Science

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07 Veterinary Awareness

US Veterinarians’ Knowledge, Experience & Perception of CBD for Dogs

63% of vets had discussed CBD with clients, and most agreed there is a need for more clinical research — reflecting growing veterinary interest.

Frontiers in Veterinary Science

Read Study →

Ready to Make the Switch?

Products Built on Proven Science

Every King Kanine formula is crafted with the same care and rigor reflected in these published studies.