Peer-Reviewed Research
The Science Behind
King Kanine
We don't just claim our CBD works — we back it with published, peer-reviewed science. Every formula is built on a foundation of real research.
Why It Matters
A History Rooted in Science
Cannabis has been cultivated for over 10,000 years, and published CBD studies date back to the 1980s. The endocannabinoid system — the biological network CBD interacts with — is not unique to humans. It exists across mammals, birds, reptiles, and fish.
At King Kanine, we believe pet owners deserve access to the same rigorous science that guides veterinary professionals. Every study below has been published in a peer-reviewed journal and is freely accessible for your review.
All mammals share the ECS — the same system CBD interacts with in humans.
Multiple studies use the gold standard randomized, placebo-controlled methodology.
Research published by Baylor University, Frontiers, and leading veterinary journals.
Landmark Study
A Randomized, Double-Blind, Placebo-Controlled Study of Daily CBD for Canine Osteoarthritis Pain
"Dogs treated with CBD showed significant improvement in pain scores and mobility. 2mg/kg of CBD twice daily can help increase comfort and activity in dogs with OA."Read the Full Study →
Published Research
All 8 Studies
Ashwagandha and Stress/Anxiety in Dogs
Ashwagandha supplementation was associated with reduced stress markers and calmer behavior in dogs during stressful situations.
ScienceDirect — Veterinary Behavioural Science
Read Study →Cannabidiol in Canine Epilepsy
CBD treatment significantly reduced seizure frequency in dogs with idiopathic epilepsy compared to placebo.
ScienceDirect — Journal of Veterinary Internal Medicine
Read Study →Long-Term Daily Feeding of CBD is Well-Tolerated by Healthy Dogs
Daily CBD supplementation over 6 months showed no adverse health effects and was well-tolerated across all dose groups.
Frontiers in Veterinary Science
Read Study →Effect of CBD on Canine Inflammatory Response
CBD demonstrated a meaningful reduction in inflammatory markers in canine whole blood — supporting its use for inflammatory conditions.
MDPI — Veterinary Sciences
Read Study →CBD in Dogs: Comparing Nasal, Oral, and Rectal Administration
Oral administration achieved the most consistent and sustained plasma CBD levels — validating oil and treat formats for daily use.
Frontiers in Veterinary Science
Read Study →Randomized Double-Blind Placebo-Controlled Study — Canine OA Pain
2mg/kg CBD twice daily produced significant improvement in pain and mobility scores. The gold standard for CBD pain research in dogs.
Baylor University — Pain Journal, 2020
Read Study →US Veterinarians’ Knowledge, Experience & Perception of CBD for Dogs
63% of vets had discussed CBD with clients, and most agreed there is a need for more clinical research — reflecting growing veterinary interest.
Frontiers in Veterinary Science
Read Study →Randomized Blinded Controlled Clinical Trial — Seizure Frequency in Dogs with Antiepileptic Treatment
Clinical trial examining CBD's effect on seizure frequency alongside conventional antiepileptic treatments in dogs.
Peer-Reviewed Clinical Trial
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Products Built on Proven Science
Every King Kanine formula is crafted with the same care and rigor reflected in these published studies.