August 01, 2022 7 min read

Content Description:

World consumption of CBD products for pets is growing. The factor that has fueled CBD's appeal, in addition to its advantages in treating a wide range of medical conditions, is its low potential for adverse side effects. Today, a growing number of people are interested in adopting CBD as an additional treatment for a variety of health issues affecting both themselves and their four-legged pets. CBD is a fantastic choice if you're searching for a solution to keep them healthy and content. CBD drug interactions in dogs are quite similar to those in people. We go into more information about this in this article.

Article Description:

Cannabidiol (CBD) has the potential to interact with other veterinary drugs, which is something owners need to be aware of. This article starts by highlighting the use of CBD Oil for dogs and examines the potential of CBD oil in enhancing the effect of prescription medications. The article further deals with the crucial question- Can CBD oil for dogs be used with other medications? We continue to explain, in detail, the medications not compatible with CBD oil. The article finally concludes with the significance of seeing your veterinarian before providing your dog any kind of CBD product if they are receiving other medications.

CBD Oil for Dogs

Cannabidiol, also known as CBD, is a naturally occurring compound that can be found in the cannabis plant. Your pet buddies can benefit greatly from medicinal cannabis and the wide variety of advantages it offers. According to studies, strain, stress, anxiety, and other bone and heart issues can positively affect your dogs as well. It also interacts with the animal's body receptors like how it does with humans. Dog treats, oils, lotions, topicals, and tinctures made from CBD and hemp is a good source for your four-legged pals to receive all the benefits they are entitled to. If you're seeking a natural way to boost their health, relax their mind, and reduce their joint pain, using CBD oil seems to be the best approach. It contributes to the happiness and contentment of your dog. Dogs experiencing situational or relocation anxiety, behavior issues, or insomnia can also benefit from the use of CBD.

Does CBD enhance the effect of other drugs?

Some medications may work better when certain substances, like CBD, are added. Some medical professionals, researchers, and veterinarians are investigating how this can be advantageous since less of the drug needs to be provided to be effective because it stays in the bloodstream longer.

For instance, some studies have suggested that CBD may improve the effects of some medications due to its impact on CYP450 pathways and other intricate signaling processes in the central nervous system. This might enable medical professionals to lower the dosage of those medications without lowering their efficacy.

This boosting effect, which is frequently referred to as a "catalytic activity," is still very much under study. Ongoing research demonstrates this impact on:

  • NSAIDs and narcotics for treating pain
  • Anti-seizure drugs for seizures in patients
  • Radiotherapy drugs used in a pancreatic cancer investigation.

Can CBD Oil for dogs be used with other medications?

The reaction between CBD and the other medication your dog is taking is known as a dog CBD interaction. Due to reports of positive behavioral and health impacts, more and more people are now adding CBD to their dog's ordinary routine. Even though CBD has anti-inflammatory, immune-modulating, and anxiety-relieving properties, it is important to be careful with potential drug interactions with the prescription medication of your dogs.

The use of medical marijuana or CBD oil by your dog, while they are taking prescribed medication may cause an interaction. This then has an impact on the cytochrome P450 family of liver enzymes.

Without getting too scientific, it is known that this specific group of enzymes is in charge of metabolizing or breaking down around 60% of clinically prescribed drugs available today, including tramadol, Xanax, and antidepressants.

Let's break things down as simply as possible. Enzyme P450 operates by introducing oxygen to the drug, making it liquid and making it simpler for the kidneys to process.

Hemp oil may prevent some enzymes from working, which would alter the liver's ability to perform metabolic tasks.

In other words, if both prescribed medication and CBD oil are consumed at the same time, there are high chances that the enzymes will only actually be able to break down one of the two. As a result, pharmaceutical drugs will often stay in the body for a longer period and have a greater impact. However, the right CBD dosage has a significant impact on this interaction. It's unlikely that your dog would notice much of a difference if you give him a tiny dose of hemp oil alongside the prescribed medication.

In light of this, you may be wondering which medications may interact.

Drug Interactions: Medications not compatible with dog CBD products.

As we've already established, not all drugs cause this drug interaction; just some do. More than half of the pharmaceutically prescribed drugs available can be metabolized by enzymes, while the fate of the other half is unknown.

To be safe, here is a list of recognized medications that, when administered in excessive doses, may interact with hemp products:

  • Benadryl
  • Antibiotics
  • Depressants
  • Morphine
  • General anesthesia

If your pet is on one or more of the medications listed above, it is crucial to consult with your vet before you purchase CBD products.

Let's take a closer look at what happens when your pet is on prescribed medication and whether CBD may be used in conjunction with that.

CBD oil interferes with anti-seizure medication:

Sudden unusual brain activity that results in a temporary loss of body control is what causes seizures. That usually results in a dog losing consciousness, collapsing over on its side, having muscle cramps, tremors, frequently shrieking, and losing control of its intestines and bladder. Numerous clinical studies have shown that CBD decreases the incidence of seizures in dogs and cats. Furthermore, it is considerably more effective when combined with common anti-seizure medications like carbamazepine or phenobarbital. The dosage can be changed. Increase CBD dosage while decreasing dosage of conventional drugs with undesirable side effects. That gives your dog the best results with the fewest adverse effects. 

CBD Oil interferes with Arthritis Medication:

It's quite improbable that CBD would, in the vast majority of situations, interfere with the metabolism of medications used to treat osteoarthritis and other aggressive joint disorders. Veterinarians frequently prescribe painkillers for old, persistently unwell, and wounded dogs. The most widely used NSAIDs for pets include gabapentin, metformin, and nonsteroidal anti-inflammatory drugs (NSAIDs), which are safe for dogs to treat pain and joint problems. However, research suggests that CBD won't interact with any NSAID medications other than Voltaren. While NSAIDs are frequently administered to dogs, simple over-the-counter drugs like Tramadol should only be administered to your dog under the guidance of your veterinarian because they can easily cross the safety boundary in canines.

CBD Oil and its interaction with cancer therapy:

Drug interactions involving CBD oil are crucial when it comes to cancer. CBD is a very well-known substance with excellent anti-tumor characteristics that are used in cancer. It aids in the relief of chemotherapy's extremely unpleasant side effects, including bleeding, discomfort, and anxiety.

Further, a wide range of studies demonstrates that CBD increases the effects of chemotherapy and kills cancer more effectively! Of course, you should speak with your veterinarian about how to change the CBD dosage for your dog's cancer therapy.

CBD Oil and its interaction with blood pressure medication:

Although high blood pressure and hypertension are more common in humans, our dogs are also prone to the condition and require similar treatment. CBD may seem like a smart idea to use in conjunction with medications made to achieve the desired results as it can lower blood pressure. It possibly aids people with hypertension. However, caution is urged. Although CBD can be used in conjunction with blood pressure drugs, it is advised that you first talk to your veterinarian about it. Aldosterone converting enzyme (ACE) inhibitors, h2-receptor antagonists (ARBs), corticosteroids, and carbamazepine are a few of the drugs used to manage high blood pressure. As a result, if your veterinarian likes the benefits CBD is providing for your pet but notices that it interacts with the medication, he might alter the medication.

CBD oil and its interaction with antidepressant medication:

Veterinarians frequently prescribe drugs like Alprazolam, Tricyclic antidepressants, Xanax, Prozac, Risperdal, and many others for dogs who experience stress, anxiety, and sorrow. On the other hand, drugs like Xanax can be habit-forming and have unpleasant side effects like sleepiness, headache, nausea, dysentery, and even clouded eyesight.

Drug interactions with CBD oil could make some negative effects worse. Therefore, the correct dosage is crucial. To reduce negative side effects and dosage of current medications, utilize CBD oil for pets. Naturally, CBD will make a lower dose more effective while having fewer negative effects!

Discuss CBD oil drug interactions with your veterinarian.

Numerous health advantages of CBD can help improve your dog’s condition in both subtle and profound ways. Research has demonstrated that CBD oil and other CBD products are remarkably low-risk choices for the advantages they bring. While it is possible to combine CBD with other medications, doing so may increase the likelihood that the medication will have negative consequences. Although not all pharmaceuticals can interact, most medications have the potential to do so.

Your best bet for advice is your pet's veterinarian if your dog is taking medicine and you have questions regarding CBD and its potential for drug interactions. Even though CBD may interact with the drugs your pet is on, your veterinarian can safely determine if CBD is still the best option for them. The best of both worlds can frequently be achieved by timing out the pills or altering the dose of the other drugs or CBD.

Even when there is a chance for drug interaction, according to current research, CBD can offer a treatment plan as an indispensable tool for enhancing health without having any real adverse reactions.


The use of CBD has many health benefits, including pain relief. Even though there may be drug interactions that result in side effects with certain medications, the advantages outweigh the disadvantages. However, as is often said, too much of anything is good for nothing; veterinarians frequently caution that too much CBD may mess with your pet's body chemistry.

Therefore, it should always be your primary responsibility to speak with your veterinarian before using any kind of pet medication for your dog’s well-being.